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Smiles: CCOC(=O)C1=CC(N)=C(C=C1)NC1CCCCC1
PMID: 30384585
EW-7197 Hydrochloride also inhibits the epithelial-to-mesenchymal transition (EMT) in both TGFβ-treated breast cancer cells and 4T1 orthotopic-grafted mice
Chemical Name: N4-cyclopropyl-6-(2
Hesperadin C sodium Smiles: CCOC(=O)C1=CC(N)=C(C=C1)NC1CCCCC1Hesperadin is an inhibitor of human Aurora B, which can prevent the phosphorylation of substrate with IC(50) of 40 nM. Growth of cultured bloodstream forms was also sensitive to Hesperadin (IC(50) of 50 nM). Hesperadin blocked nuclear division and cytokinesis but not other aspects of the cell cycle. Consequently, growth arrested cells accumulated multiple kinetoplasts, flagella and nucleoli, similar to the effects of RNAi dependent knockdown of TbAUK1
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